But mind you, you should always check if a shortcut is not already taken by the OS and that can differ by OS or even terminal type (e.g. on Windows alt-tab, alt-F4 etc.)
You should also check if there are common standards for the type of application that you write and try to adhere to that.That will make it easier for the end user, because it may be familiar. E.g. Lazarus mimics a great deal of the Delphi shortcuts.