heebiejeebies, I, or rather an end user of mine, experienced something like this and we eventually decided it was because he was using an open source file encryption tool, the name of which I cannot remember. (A new version of that file encryption fixed his problem, U18.04 is starting to show its age.) Do you have anything like that running ? Or is the file in question mounted as some sort of share, smb, nfs etc ?
WRT your message to Mark, I sort of agree but you really do need to understand how frustrating it can be when people ask questions without at least telling us the very, very basic information needed. But we all get along pretty well here usually ....
Davo