AFAIK this is not possible because it is the behaviour of the underlying OS widget, and TComboBox does not implement an OnMouseWheel event which you could hook to disable anything (it is protected in the ancestor). In fact even setting Enabled to False for a combobox does not prevent this underlying widget behaviour. Setting Style to ownerdrawn does not help either, since that paints the dropdown, not the edit field area where the scrolling happens.