Some very few of them are on
https://wiki.freepascal.org/GDB_Debugger_TipsEspecially: DisableLoadSymbolForLibraries.
Many of the others are to work around issues in some versions of gdb.
E.g. all the "quoting" options are only needed if you get errors, and the IDE shows the statement in question had some quoted data (e.g. filename). If you don't get those errors, then you don't need them.
MemLimits... (not sure if they are documented somewhere)
They should map exactly to the relevant configurations for gdb. The IDE will updated them depending on what data it fetches (stack or watches).
This protects from crashes when types are declared that use excessive memory
type
TFoo = array [MinInt..MaxInt] of QWord;
PFoo = ^TFoo;
variables can only be declared for PFoo, but if the debugger tries to deref them....
Many of the others I need to go diving into the code myself.