What happens if I already have some translations files, but add new resources to my project? Will the *.pot file be updated automatically? And would POEdit notice that, say, *.de_DE.po is now missing some items that are new in *.pot? Or do I have do manage/merge manually?
Normally this is done in a transparent/automatic way when "Create/update .po file when saving lfm file" is checked in the i18n project options. You may also want to check "Force update PO files on next build" - but this will uncheck itself after the next build, iirc. If, in rare cases, the pot/po files are not updated, do a "Run" > "Build", or "Run" > "Clean up and Build", or "Project" > "Resave forms with enabled i18n" (can't remember which one is most effective...)
Be careful with .lrj files. They are important for the translation system. Do not delete them, add them to the repository if you use version control (git, svn).
When new resoure strings or controls with translated texts are added to a form, the items are added to the po/pot files, their translation will be empty. Load each po into POEdit, seek for untranslated items (empty lines at the right side of the text list) and update them.
Yes, I noticed the slight stupidity of the question myself.
There are no stupid questions.