I still don't understand how the two images relate to each other. If the right image is the upscaled 100% image then why are the texts different?
In my own test, I did not see an effect whether "DPI awareness" is off or on ("Project options" > "Application" > "For windows"), but according to the wiki site it should be on, you have it off.
Another problem can occur if you use both 100% and 150% systems for designing. Because every time the form designed in one resolution is opened in the system with the other resolution the pixel coordinates are recalculated for the new resolution. If you save the form in this resolution and open it again in the first resolution dimension may change slightly due to roud-off errors.
[EDIT]
I see another difference between the left and right screenshots: the left one is themed, the right one not. You should not expect DPI scaling to work exactly between themed and non-themed instances of the same application. System-dependent sizes (such as radiobutton or checkbox sizes) will be different even at 100%.
If you must consider your programs to run in various themes you must not provide some extra space.